yohimbine manufacturer

Product Name :
Chemical Formula :
17?-hydroxy-yohimban-16?-carboxylic acid methyl ester
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Description :
Yohimbine is an alkaloid with stimulant and aphrodisiac effects found naturally in Pausinystalia yohimbe (Yohimbe). It is also found naturally inRauwolfia serpentina (Indian Snakeroot), Alchornea floribunda (Niando), along with several other active alkaloids. Yohimbine has been used as both an over-the-counter dietary supplement in herbal extract form and prescription medicine in pure form for the treatment of sexual dysfunction. Yohimbine was explored as a remedy for type 2 diabetes in animal and human models carrying polymorphisms of the ?2A-adrenergic receptor gene. Yohimbine has high affinity for the ?2-adrenergic receptor, moderate affinity for the ?1-adrenergic, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.[16][17] It behaves as an antagonist at ?1-adrenergic, ?2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and D2, and as a partial agonist at 5-HT1A.[16][18][19][20] Its intrinsic activities at the other sites listed are unclear/unknown, but it is probably mostly antagonistic at them.

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