tadalafil manufacturer

Product Name :
TADALAFIL
Chemical Formula :
(6R-trans)-6-(1,3-benzodioxol-5-yl)- 2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1', 2':1,6] pyrido[3,4-b]indole-1,4-dione
CAS No :
171596-29-5
Molecular Formula :
C22H19N3O4 
Molecular Weight :
389.404
tadalafil
Description :
Tadalafil is a PDE5 inhibitor, is used in pill form for treating erectile dysfunction (ED) for the treatment of pulmonary arterial hypertension. Tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) – compared to Viagra (4.0–5.0 hours) and Levitra (4.0–5.0 hours) – resulting in longer duration of action. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP relaxes smooth muscle and increases blood flow to the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. In patients with pulmonary arterial hypertension, the pulmonary vascular lumen is decreased as a result of vasoconstriction and vascular remodeling, resulting in increased pulmonary artery pressure and pulmonary vascular resistance. Tadalafil is believed to increase pulmonary artery vasodilation, and inhibit vascular remodeling, thus lowering pulmonary arterial pressure and pulmonary vascular resistance. Right heart failure is the principal consequence of pulmonary arterial hypertension.

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