spironolactone manufacturer

Product Name :
Chemical Formula :
7?-acetylthio-3-oxo-17?-pregn-4-ene-21,17-carbolactone or 17-hydroxy-7?-mercapto-3-oxo-17?-pregn-4-ene-21-carboxylic acid, ?-lactone acetate
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Description :
Spironolactone  commonly referred to simply as "spiro" is a synthetic, steroidal antimineralocorticoid agent with additional antiandrogen and weakprogestogen properties, as well as some indirect estrogen and glucocorticoid effects, which is used primarily as a diuretic and antihypertensive, but also for the purpose of reducing elevated or unwanted androgen activity in the body. It acts predominantly as a competitive antagonist of the aldosterone (or mineralocorticoid) receptor, and belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics. Spironolactone is frequently used as an antiandrogen. Spironolactone is used primarily to treat heart failure, ascites in patients with liver disease, low-renin hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and Conn's syndrome (primary hyperaldosteronism). Spironolactone is a potent antagonist of the androgen receptor as well as an inhibitor of androgen production. Due to the antiandrogen effects that result from these actions, it is frequently used to treat a variety of cosmetic conditions in which androgen hormones such as testosterone and dihydrotestosterone (DHT) play a role, including hirsutism, androgenic alopecia, acne, and seborrhea in females. It is also commonly used to treat symptoms of hyperandrogenism in polycystic ovary syndrome.

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