ramipril manufacturer

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Chemical Formula :
(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
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Description :
Ramiprilis anangiotensin-converting enzyme (ACE) inhibitor, used to treathigh blood pressureandcongestive heart failure. ACE inhibitors, as the name suggests, inhibit the actions of angiotensin converting enzyme (ACE), thereby lowering the production of angiotensin II and also decreasing the breakdown of bradykinin. The decrease in angiotensin II results in relaxation of arteriole smooth muscle leading to a decrease in total peripheral resistance, reducing blood pressure as the blood is pumped through larger diameter vessels. Its effect on bradykinin is responsible for the dry cough side effect. Ramipril, a prodrug, is converted to the active metabolite ramiprilat by liver esterase enzymes.Ramiprilat is mostly excreted by the kidneys. The half-life of ramiprilat is variable (316 hours), and is prolonged by heart and liver failure, as well as kidney failure.

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