pyrazinamide manufacturer

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Description :
Pyrazinamide is a drug used to treat tuberculosis. The drug is largely bacteriostatic, but can be bacteriocidal on actively replicating tuberculosisbacteria. Pyrazinamide is only used in combination with other drugs such as isoniazid and rifampicin in the treatment of Mycobacterium tuberculosis. Pyrazinamide is used in the first two months of treatment to reduce the duration of treatment required. Regimens not containing pyrazinamide must be taken for nine months or more. Pyrazinamide in conjunction with rifampin is a preferred treatment for latent tuberculosis. Pyrazinamide is a potent antiuricosuric drug and consequently has an off-label use in the diagnosis of causes of hyperuricemia and hyperuricosuria. It acts on URAT1. Pyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. Pyrazinamide diffuses into M. tuberculosis, where the enzyme pyrazinamidase converts pyrazinamide to the active form pyrazinoic acid. Under acidic conditions, the pyrazinoic acid that slowly leaks out converts to the protonated conjugate acid, which is thought to diffuse easily back into the bacilli and accumulate.

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