promethazine manufacturer

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Description :
Promethazine is a first-generation antihistamine of the phenothiazine family. The drug has anti-motion sickness, antiemetic, and anticholinergiceffects, as well as a strong sedative effect. Promethazine is a phenothiazine derivative that is structurally different from the neuroleptic phenothiazines, with similar but different effects. It acts primarily as a strong antagonist of the H1 receptor (antihistamine) and a moderate mACh receptor antagonist (anticholinergic), and also has weak to moderate affinity for the 5-HT2A, 5-HT2C, D2, and ?1-adrenergic receptors, where it acts as an antagonist at all sites as well. Another notable property of promethazine is that it is a local anesthetic, via blockade of sodium channels.

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