loperamide manufacturer

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Loperamide  a synthetic piperidine derivative is an opioid drug used against diarrhea resulting from gastroenteritis or inflammatory bowel disease. Loperamide is an opioid-receptor agonist and acts on the ?-opioid receptors in the myenteric plexus of the large intestine; by itself it does not affect the central nervous system. It works by decreasing the activity of the myenteric plexus, which, like morphine, decreases the tone of the longitudinal smooth muscles but increases the tone of circular smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.

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