human-chorionic-gonadotropin manufacturer

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Description :
Human chorionic gonadotropin (hCG) is a hormone produced during pregnancy that is made by the developing placenta afterconception, and later by the placental component syncytiotrophoblast. The pituitary analogue of hCG, known as luteinizing hormone (LH), is produced in the pituitary gland of males and females of all ages. It is heterodimeric, with an ? (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and ? (beta) subunit that is unique to hCG. The ? (alpha) subunit is 92 amino acids long. The sequence of the alpha unit can be found on UniProtKB with ID: P01215[25-116]. The ?-subunit of hCG gonadotropin contains 145 amino acids, encoded by six highly homologous genes that are arranged in tandem and inverted pairs on chromosome 19q13.3 - CGB (1, 2, 3, 5, 7, 8). The sequence of the beta unit can be found on UniProtKB with ID: P01233[21-165]. The two subunits create a small hydrophobic core surrounded by a high surface area-to-volume ratio: 2.8 times that of a sphere. The vast majority of the outer amino acids are hydrophilic.

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